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“青年千人计划”入选者,博导——夏小俊
发布日期:2017/3/6 18:56:21  阅读:3218  来自:本站

    个人简介

     怀宁县小市镇禅师村王夏屋人

  男,国家第十一批“青年千人计划”入选者,中山大学肿瘤防治中心华南肿瘤学国家重点实验室研究员、博士生导师。

  个人经历

  2007年毕业于美国得克萨斯大学MD安德森癌症中心(University of Texas MD Anderson Cancer Center),获得癌症生物学专业博士,随后在贝勒医学院 (Baylor College of Medicine)和休斯顿卫理会医院研究所(Houston Methodist Research Institute)进行博士后研究和从事讲师工作,2015年入选中组部“青年千人计划”。现为中山大学肿瘤防治中心,华南肿瘤学国家重点实验室研究员、博士生导师。

  研究方向

  长期从事肿瘤生物学和肿瘤免疫学研究,在天然免疫反应信号通路,肿瘤炎症的分子机制,以及利用纳米材料开发新型抗肿瘤药物方面具有丰富经验,研究成果发表于Cell,Immunity, Cell Reports等重要国际期刊。目前研究领域集中在天然免疫对于肿瘤微环境的调控机制,以及如何通过物理,化学和生物手段干预肿瘤微环境(包括免疫微环境和代谢微环境)来逆转免疫抑制和增强肿瘤免疫治疗效果。

  学术成果

   代表性论文

  1. Xia X., Mai J., Xu R., Perez J., Guevara, L., Shen Q., Mu C., Tung H.Y., Corry D.B., Evans S.E., Liu X., Ferrari M., Zhang Z., Li XC, Wang R-F, Shen H. Porous silicon microparticle potentiates anti-tumor immunity by enhancing antigen cross-presentation and inducing type I interferon response. Cell Reports, 2015, May 12, 11,957-966.

  2. Xia X*, Liu S*, Xiao Z*, Zhu F, Song NY, Zhou M, Liu B, Shen J, Nagashima K, Veenstra TD, Burkett S, Datla M, Willette-Brown J, Shen H, Hu Y. An IKKa-Nucleophosmin axis utilizes inflammation signaling to promote genomic instability. Cell Reports, 2013 Dec 12;5(5):1243-55. doi: 10.1016/j.celrep.2013.10.046. (* 共同第一作者)(Cell新子刊,影响因子7.207)

  3. Xia X, Park E, Fischer SM, Hu Y. Mouse Genetic Models Reveal Surprising Functions of IkB Kinase Alpha in Skin Development and Skin Carcinogenesis. Cancers (Basel). 2013 Feb 15;5(1):170-83. doi: 10.3390/cancers5010170.

  4. Mai J, Huang Y, Mu C, Zhang G, Xu R, Guo X, Xia X, Volk DE, Lokesh GL, Thiviyanathan V, Gorenstein DG, Liu X, Ferrari M, Shen H. Bone marrow endothelium-targeted therapeutics for metastatic breast cancer. J Control Release. 2014 Aug 10;187:22-9. (影响因子:7.261)

  5. Zhang M, Xu R, Xia X, Yang Y, Gu J, Qin G, Liu X, Ferrari M, Shen H. Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells. Biomaterials. 2014 Jan;35(1):423-31. (影响因子:7.404)

  6. Xu R, Huang Y, Mai J, Zhang G, Guo X, Xia X, Koay EJ, Qin G, Erm DR, Li Q, Liu X, Ferrari M, Shen H. Multistage vectored siRNA targeting ataxia-telangiectasia mutated for breast cancer therapy. Small. 2013 May 27;9(9-10):1799-808. (影响因子:7.514)

  7. Shen J, Xu R, Mai J, Kim HC, Guo X, Qin G, Yang Y, Wolfram J, Mu C, Xia X, Gu J, Liu X, Mao ZW, Ferrari M, Shen H. High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics. ACS Nano. 2013 Nov 26;7(11):9867-80. (影响因子: 12.033)

  8. Fan J, Huang Y, Finoulst I, Wu HJ, Deng Z, Xu R, Xia X, Ferrari M, Shen H, Hu Y. Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay. Cancer Letter. 2012 Nov 27. Doi:pii:S0304-3835 (12)00658-1. (影响因子:4.238)

  9. Alagbala Ajibade A., Wang Q., Cui J., Zou J., Xia X., Wang M., Tong Y., Hui W., Liu D., Su B., Wang H.Y. Wang RF. TAK1 negatively regulates NF-κB and p38 MAP Kinase activation in Gr-1(+)CD11b(+) neutrophils. Immunity, 2012, Jan 27;36(1):43-54. (影响因子:21.637)

  10. Xia, X. *, Cui J.*, Wang H.Y., Zhu L., Matsueda, S., Wang Q.F., Chen Z.J., Wang RF. NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. Immunity, 2011, June 24, 34(6): 843-53. (* 共同第一作者) (影响因子:21.637)

  11. Cui J.*, Zhu L.*, Xia X.*, Wang HY, Legras, X., Hong J., Ji J., Shen PP, Zheng S, Chen ZJ, Wang RF. NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways. Cell, 2010, April 30, 141(3) : 483-496. (* 共同第一作者) (影响因子:32.403)

  12. Xia, X., Park E., Liu B., Willette-Brown J., Gong W, Wang, J., Mitchell, DL., Fischer SM, Hu, Y. Reduction of IKKa expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. American Journal of Pathology, 2010 May, 176(5): 2500-8. (影响因子:4.89)

  13. Liu, B., Xia, X., Carbajal, S., Fischer, SM., DiGiovanni, J., Hu, Y. IKKa deletion in keratinocytes causes cell-autonomous epidermal hyperplasia that is rescued by inactivation of the EGF receptor. Cancer Cell. 2008 Sep 9;14(3):212-25. (影响因子:26.566)

  14. Zhu, F., Xia, X., Liu, B., Hu, Y., Hu, Y. IKKa shields 14-3-3s, a G2/M cell cycle checkpoint, from hypermethylation, preventing its silencing. Molecular Cell. 2007 Jul 20;27(2):214-27. (影响因子:14.178)

  15. Kleiner HE, Xia X., Sonoda J, Zhang J, Pontius E, Abey J, Evans RM, Moore DD, Digiovanni J. Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. Toxicol Appl Pharmacol. 2008 Oct 15; 232(2): 337-50. (影响因子:4.447)

  16. Park, E., Zhu, F., Liu, B., Shen, J., Xia, X., Bustos, T., Person, M., Fischer, SM., Hu Y. Reduction in IκB Kinase α expression promotes the development of skin papillomas and carcinomas. Cancer Res. 2007 Oct 1;67(19):9158-68. (影响因子:7.856)

 

     
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